Abstract
To evaluate the risk factors for hypercholesterolemia, we examined 4,371 subjects
(3,207 males and 1,164 females) who received medical checkups more than twice at an
AMHTS in Tokyo during the period from 1976 through 1991; and whose serum total cholesterol
was under 250 mg/dl. The mean follow-up duration was 6.6 years. A self-registering
questionnaire was administered at the time of the health checkup. The endpoint of
this study was the onset of hypercholesterolemia when the level of serum total cholesterol
was 250 mg/dl and over. We compared two prognosis groups (normal and hypercholesterol)
in terms of age, examination findings and lifestyle. After assessing each variable,
we employed Cox's proportional hazards model analysis to determine the factors related
to the occurrence of hypercholesterolemia. According to proportional hazards model
analysis, total cholesterol, triglyceride and smoking at the beginning, and hypertension
during the observation period were selected in males; and total cholesterol at the
beginning and age were selected in females to determine the factors related to the
occurrence of hypercholesterolemia.
Keywords
Health Evaluation - Health Risk Appraisal - Risk Factor - Cholesterol - Proportional
Hazards Model
